Recombinant Human 15-PGDH Protein (His Tag)

Specifications

Catalog number

PKSH033377-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

15-hydroxyprostaglandin dehydrogenase [NAD (+) ], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.

Abbreviation

15-PGDH

Synonyms

15-Hydroxyprostaglandin Dehydrogenase [NAD (+) ];15-PGDH; HPGD; PGDH; PGDH1; PHOAR1; Prostaglandin Dehydrogenase 1; SDR36C1

Accession Number

P15428

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Gln266

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

30 kDa

Observed Molecular Weight

29 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4.

Species

Human