Recombinant Human SH2D1A/SAP Protein (His Tag)

Specifications

Catalog number

PKSH033379-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SH2 Domain-Containing Protein 1A, (SH2D1A) contains one SH2 domain and a short tail and is localized in the cytoplasm. SH2D1A is expressed at a high level in the thymus and the lung, with lower expression levels in the spleen and the liver. SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. In addition, SH2D1A mediates interaction between FYN and SLAMF1. It is also thought to regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Abbreviation

SH2D1A; SAP

Synonyms

DSHP; Duncan Disease SH2-Protein; EBVS; IMD5; LYP; MTCP1; SAP/SH2D1A; SH2 Domain-Containing Protein 1A; SH2D1A; SLAM-Associated Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; T-Cell Signal Transduction Molecule SAP; XLP; XLPD; XLPD1

Accession Number

O60880

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Pro128

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

16.4 kDa

Observed Molecular Weight

16 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.

Species

Human