Recombinant Human Kallikrein 7/KLK7 Protein (His Tag)

Specifications

Catalog number

PKSH033421-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

Abbreviation

Kallikrein 7; KLK7

Synonyms

KLK7; Kallikrein-7; PRSS6; SCCE; Serine Protease 6; Stratum Corneum Chymotryptic Enzyme; hK7; hSCCE

UniProt

P49862

Accession Number

AAH32005

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu23-His252

Field of Research

Signal Transduction; Cell biology; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

26.2 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5.

Species

Human