Recombinant Human TRAIL Protein

Specifications

Catalog number

PKSH033422-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.

Abbreviation

TRAIL

Synonyms

APO2L; Apo-2 Ligand; Apo-2L; CD253; Protein TRAIL; TNF-Related Apoptosis-Inducing Ligand; TNFSF10; TRAIL; Tumor Necrosis Factor Ligand Superfamily Member 10

UniProt

P50591

Accession Number

P50591

Expression System

E.coli

Tag

C-His

Sequence

Arg115-Gly281

Applications

Cell culture

Field of Research

Cell biology; Cardiovascular; Cancer

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.3 kDa

Observed Molecular Weight

18 kDa

Species

Human