Recombinant Human PGD Protein (Human Cells, His Tag)

Specifications

Catalog number

PKSH033424-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

6-phosphogluconate dehydrogenase (PGD) is a cytoplasm-located protein; and belongs to the 6-phosphogluconate dehydrogenase family. 6PGD is the second dehydrogenase in the pentose phosphate shunt. It catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2; with concomitant reduction of NADP to NADPH. Mutations within the gene coding this enzyme result in 6-phosphogluconate dehydrogenase deficiency; an autosomal hereditary disease effecting the red blood cells.

Abbreviation

PGD

Synonyms

6-phosphogluconate dehydrogenase;6PGD; Decarboxylating; PGD; PGDH

UniProt

P52209

Accession Number

P52209

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ala483

Field of Research

Signal Transduction; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

54.2 kDa

Observed Molecular Weight

58 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Species

Human