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Product details

Recombinant Human GFRRA2 Protein (His Tag)

Catalog number PKSH033430-01

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Price for PKSH033430-01

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Size / count 10 µg

Specifications

Catalog number
PKSH033430-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and Neurturin, play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2, and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFRα-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.
Abbreviation
GFRRA2
Synonyms
GDNF Family Receptor Alpha-2; GDNF Receptor Alpha-2; GDNF Receptor Beta; GDNFR-Alpha-2; GDNFR-Beta; GDNFRB; GFR-Alpha-2; GFRA2; NRTNR-Alpha; NTNR-Alpha; Neurturin Receptor Alpha; RET Ligand 2; RETL2; TGF-Beta-Related Neurotrophic Factor Receptor 2; TRNR2
Accession Number
O00451
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser22-Ser441
Field of Research
Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
47.8 kDa
Observed Molecular Weight
80 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human GFRRA2 Protein (His Tag)?

The catalog number for Recombinant Human GFRRA2 Protein (His Tag) is PKSH033430.

What sizes are available for Recombinant Human GFRRA2 Protein (His Tag)?

Recombinant Human GFRRA2 Protein (His Tag) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human GFRRA2 Protein (His Tag) come in?

Recombinant Human GFRRA2 Protein (His Tag) is available in 2 different pack sizes.

Is Recombinant Human GFRRA2 Protein (His Tag) in stock?

Recombinant Human GFRRA2 Protein (His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human GFRRA2 Protein (His Tag)?

Recombinant Human GFRRA2 Protein (His Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human GFRRA2 Protein (His Tag)?

Estimated delivery time for Recombinant Human GFRRA2 Protein (His Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human GFRRA2 Protein (His Tag)?

The safety data sheet for Recombinant Human GFRRA2 Protein (His Tag) is available here: https://789.bio/eb/5GiDyP.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

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