Recombinant Human Fas/CD95/TNFRSF6 Protein (His Tag)

Specifications

Catalog number

PKSH033436-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FAS is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Abbreviation

Fas; CD95; TNFRSF6

Synonyms

ALPS1A; APO-1; APT1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; CD95; FAS1; FASLG receptor; FASTM; TNFRSF6 and FAS; Tumor necrosis factor receptor superfamily member 6

Accession Number

P25445

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln26-Asn173

Field of Research

Cell biology; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17.7 kDa

Observed Molecular Weight

22-35 kDa

Species

Human