Recombinant Human Factor D Protein (His Tag)

Specifications

Catalog number

PKSH033442-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Complement factor D; also known as adipsin; is a member of the chymotrypsin family of serine proteases; which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3; which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes; including immunity and inflammation.

Abbreviation

Factor D

Synonyms

ADIPSIN; ADN; Adipsin; C3 convertase activator; CFD; Complement factor D; DF; FACTOR D; PFD; Properdin factor D

UniProt

P00746

Accession Number

P00746

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ile26-Ala253

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

25.8 kDa

Observed Molecular Weight

28 kDa

Formulation

2

Species

Human