Recombinant Human CNDP1 Protein (His Tag)

Specifications

Catalog number

PKSH033451-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Carnosine Dipeptidase 1 (CNDP1) belongs to the M20 metalloprotease family. CNDP1 is specifically expressed in the brain; serum and adult nervous central system. It is identified as human carnosinase. CNDP1 contains trinucleotide (CTG) repeat length polymorphism in the coding region and is inhibited by the metal chelator 1;10-o-phenantrolin. In addition; CNDP1 can hydrolyse the beta-Ala|-His dipeptide (carnosine) ; anserine; Xaa-|-His dipeptides and other dipeptides including homocarnosine. CNDP1 deficiency has been associated with homocarnosinosis disease.

Abbreviation

CNDP1

Synonyms

Beta-Ala-His Dipeptidase; CN1; CNDP Dipeptidase 1; CNDP1; CPGL2; Carnosine Dipeptidase 1; Glutamate Carboxypeptidase-Like Protein 2; HsT2308; Serum Carnosinase

Accession Number

AAI13513.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Pro28-His507

Field of Research

Signal Transduction; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

54.9 kDa

Observed Molecular Weight

60-90 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5.

Species

Human