Recombinant Human HABP2 Protein (His Tag)

Specifications

Catalog number

PKSH033464-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hyaluronan-binding protein 2 (HABP2) is an extracellular serine protease which binds hyaluronic acid. It secreted as an inactive single-chain precursor and is then activated to a heterodimeric form, which consists of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond. HABP2 is involved in cell adhesion, it can cleave the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' , but not the gamma-chain of fibrinogen. As a result of this, it does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator to the active two chain form, activates coagulation factor VII.

Abbreviation

HABP2

Synonyms

Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Hyaluronan-binding protein 2; Plasma hyaluronan-binding protein

UniProt

Q14520

Accession Number

Q14520

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Gln279

Field of Research

Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

32.7 kDa

Observed Molecular Weight

35-40 kDa

Species

Human