Recombinant Human VEGF-B/VEGFB Protein (Fc Tag)

Specifications

Catalog number

PKSH033474-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

VEGFB, as known as VRF, is a member of the VEGF family of growth factors that share structural and functional similarity. By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. The two VEGF-B isoforms have identical amino-terminal cysteine-knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. VEGF-B167 and a proteolytically processed form of VEGF-B186 also bind neuropilin-1, a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance.

Abbreviation

VEGF-B; VEGFB

Synonyms

VEGF-B; VEGF-related factor; VRF; Vascular endothelial growth factor B

UniProt

P49765

Accession Number

P49765

Expression System

HEK293 Cells

Tag

N-Fc

Sequence

Pro22-Ala207

Field of Research

Signal Transduction; Cardiovascular; Neuroscience; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

45.7 kDa

Observed Molecular Weight

40&60 kDa

Species

Human