Recombinant Human ROR2 Protein (His Tag)

Specifications

Catalog number

PKSH033479-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor Tyrosine Kinaselike Orphan Receptor 2 (ROR2) belongs to the protein kinase superfamily, Tyr protein kinase family and ROR subfamily. It is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. ROR2 promotes osteogenesis, binds YWHAB and Interacts with WTIP. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cellpolarization, and migration. ROR2 has also been shown to have very little tyrosine kinase activity in vitro and may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Abbreviation

ROR2

Synonyms

NTRKR2; Neurotrophic tyrosine kinase; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2; receptor-related 2

UniProt

Q01974

Accession Number

Q01974

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu34-Gly403

Field of Research

Signal Transduction; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.2 kDa

Observed Molecular Weight

50-60 kDa

Species

Human