Recombinant Human MERTK/MER Protein (His Tag)

Specifications

Catalog number

PKSH033481-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains; two Ig-like C2-type domains; and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes; but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes; such as cell survival; migration; differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells; platelet aggregation; and cytoskeleton reorganization. Not only these; it also plays an important role in inhibition of Toll-like receptors (TLRs) -mediated innate immune response by activating STAT1; which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition; MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE) ; deficiency in MERTK are the cause of retinitis pigmentosa.

Abbreviation

MERTK; MER

Synonyms

MER; MERTK; Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; Tyrosine-protein kinase Mer

UniProt

Q12866

Accession Number

Q1RMG3

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Ala323

Field of Research

Signal Transduction; Cell biology; Neuroscience; immunology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.0 kDa

Observed Molecular Weight

60-120 kDa

Species

Human