Recombinant Human BCMA/TNFRSF17 Protein (mFc Tag)

Specifications

Catalog number

PKSH033485-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain; a 23 aa transmembrane domain; and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF; it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF; members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface; BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development; function and regulation.

Abbreviation

BCMA; TNFRSF17

Synonyms

B-cell maturation protein; Bcm; Bcma; CD269; Tnfrsf17; Tumor necrosis factor receptor superfamily member 17

UniProt

Q02223

Accession Number

Q02223

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Met1-Ala54

Field of Research

Signal Transduction; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

32.5 kDa

Observed Molecular Weight

35-42 kDa

Species

Human