Recombinant Human TPP1/CLN2 Protein (His Tag)

Specifications

Catalog number

PKSH033493-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2) .

Abbreviation

TPP1; CLN2

Synonyms

CLN2; Cell Growth-Inhibiting Gene 1 Protein; GIG1; LPIC; Lysosomal Pepstatin-Insensitive Protease; SCAR7; TPP-1; TPP1; Tripeptidyl Aminopeptidase; Tripeptidyl-Peptidase 1

UniProt

O14773

Accession Number

AAH14863.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser20-Pro563

Field of Research

Cell biology; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

60.4 kDa

Observed Molecular Weight

74 kDa

Formulation

2

Species

Human