Recombinant Human Trefoil Factor 1/TFF1 Protein (His Tag)

Specifications

Catalog number

PKSH033494-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains. TFF1 is an approximately 7 kDa peptide that plays an important role in epithelial regeneration and wound healing. It is highly expressed in goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells. By conserving intrachain disulfide bonds, human TFF1 formed a three-leaved conformation held together.It is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and form non-covalent complexes with the mucin MUC5AC. TFF1 is down-regulated during the progression from gastritis to gastric dysplasia to gastric cancer, although it is up-regulated in breast and prostate cancers.

Abbreviation

Trefoil Factor 1; TFF1

Synonyms

BCEI; Breast cancer estrogen-inducible protein; PNR-2; PS2; Polypeptide P1.A; Protein Ps2; TFF1; Trefoil factor 1; hP1.A

UniProt

P04155

Accession Number

P04155

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu25-Phe84

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

7.5 kDa

Observed Molecular Weight

14 kDa

Species

Human