Recombinant Human CD3d/CD3 delta Protein (His Tag)

Specifications

Catalog number

PKSH033508-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD3D is a single-pass type I membrane protein which Contains 1 ITAM domain. T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function; and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) . Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID) ; which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity; leukopenia; and low or absent antibody levels.

Abbreviation

CD3d; CD3 delta

Synonyms

CD3D; CD3d; T-Cell Receptor T3 Delta Chain; T-Cell Surface Glycoprotein CD3 Delta Chain; T3D

UniProt

P04234

Accession Number

P04234

Expression System

HEK293 Cells

Tag

C-His

Sequence

Phe22-Ala105

Field of Research

Immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

10.6 kDa

Observed Molecular Weight

18-30 kDa

Species

Human