Recombinant Human STING/TMEM173 Protein (Sumo & His Tag)

Specifications

Catalog number

PKSH033517-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Stimulator of Interferon Gene (Sting, TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379) . It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.

Abbreviation

STING; TMEM173

Synonyms

Mediator of IRF3 activation; Stimulator of interferon genes protein; TMEM173; sting

UniProt

Q86WV6

Accession Number

Q86WV6

Expression System

E.coli

Tag

N-SUMO-His

Sequence

Val155-Val341

Field of Research

Signal Transduction; Cancer; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

33.8 kDa

Observed Molecular Weight

35 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 100mM NaCl, 10% Glycerol, pH8.0.

Species

Human