Recombinant Human CD48 Protein (mFc Tag)

Specifications

Catalog number

PKSH033522-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD48 antigen; also known as B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; TCT.1; CD48; BCM1; and BLAST1; CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain; but does not have a transmembrane domain; however; but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cell activation. CD48 plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma.

Abbreviation

CD48

Synonyms

B-lymphocyte activation marker BLAST-1; BCM1; BCM1 surface antigen; BLAST1; CD48; CD48 antigen; Leukocyte antigen MEM-102; SLAMF2; TCT.1; hCD48; mCD48

UniProt

P09326

Accession Number

P09326

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Gln27-Ser220

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.9 kDa

Observed Molecular Weight

60-80 kDa

Species

Human