Recombinant Human SAA2/Serum Amyloid A2 Protein (His Tag)

Specifications

Catalog number

PKSH033532-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Serum amyloid A-2 protein (SAA2) belongs to the SAA family. It expressed by the liver and secreted in plasma. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. Increased levels of A-SAA in serum are indicative of inflammatory disease. When highly expressed, SAA can displace ApoA1 as the major apolipoprotein in HDL complexes, weakening the function of HDL as a reverse (lipid clearing) cholesterol transporter. A highly charged region of SAA2 and SAA1 (aa 36-68) contains putative fibronectin- and laminin-binding motifs. This region also binds heparin sulfate proteoglycans at mildly acidic pH and promotes aggregation of A-SAA.

Abbreviation

SAA2; Serum Amyloid A2

Synonyms

SAA; SAA2; Serum Amyloid A2

UniProt

P0DJI9

Accession Number

AAH20795.1

Expression System

E.coli

Tag

N-His

Sequence

Arg19-Tyr122

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.2 kDa

Observed Molecular Weight

14 kDa

Species

Human