Recombinant Human Vaspin/SerpinA12 Protein (His Tag)

Specifications

Catalog number

PKSH033533-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets; nine α-helices; and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity; insulin resistance; and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.

Abbreviation

Vaspin; SerpinA12

Synonyms

OL-64; SERPINA12; Serpin A12; Vaspin; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin

UniProt

Q8IW75

Accession Number

Q8IW75

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu21-Lys414

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

46.5 kDa

Observed Molecular Weight

50-60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5.

Species

Human