Recombinant Human PDGFRa/CD140a Protein (His Tag)

Specifications

Catalog number

PKSH033564-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Platelet-derived Growth Factor Receptor Alpha (PDGF Rα) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF Rα is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF Rα autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-γ pathways. PDGF Rα has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial , cardiac neural crest and interstitial kidney mesenchyme.

Abbreviation

PDGFRa; CD140a

Synonyms

Alpha platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140A; PDGFR-2; PDGFR-alpha; PDGFR2; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor recepto; Platelet-derived growth factor receptor alpha; RHEPDGFRA

UniProt

P16234

Accession Number

P16234

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln24-Glu524

Field of Research

Signal Transduction; Cardiovascular; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

57.0 kDa

Observed Molecular Weight

93 kDa

Species

Human