Recombinant Human Cyclophilin B/PPIB Protein (His Tag)

Specifications

Catalog number

PKSH033569-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cyclophilin B (SCYLP, CyPB and peptidyl-prolyl cis-trans isomerase B) is a 24 kDa glycoprotein member of the B subfamily of the cyclophilin-type PPIase family of molecules. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones.

Abbreviation

Cyclophilin B; PPIB

Synonyms

CYP-S1; CYPB; HEL-S-39; OI9; SCYLP

UniProt

P23284

Accession Number

P23284

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp34-Ala212

Field of Research

Signal Transduction; immunology; Isotypeloading control

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.9 kDa

Observed Molecular Weight

21 kDa

Species

Human