Recombinant Human NACHRA5/CHRNA5 Protein (His Tag)

Specifications

Catalog number

PKSH033582-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neuronal Acetylcholine Receptor Subunit α-5 (NACHRA5) is a member of the ligand-gated ion channel family. Neuronal AChR is composed of two different type of subunits: α and non-α. When NACHRA5 binds to acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits, leading to the opening of an ion-conducting channel across the plasma membrane. Genetic variations in NACHRA5 have been related to susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3.

Abbreviation

NACHRA5; CHRNA5

Synonyms

CHRNA5; NACHRA5; Neuronal Acetylcholine Receptor Subunit Alpha-5

UniProt

P30532

Accession Number

P30532

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg23-Thr254

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

27.6 kDa

Observed Molecular Weight

35-47 kDa

Species

Human