Recombinant Human MMP-3 Protein (His Tag)

Specifications

Catalog number

PKSH033591-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling.[3] The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

Abbreviation

MMP-3

Synonyms

CHDS6; MMP-3; MMP3; Matrix metalloproteinase-3; SL-1; STMY; STMY1; STR1; Stromelysin-1; Transin-1

UniProt

P08254

Accession Number

AAA36321.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Tyr18-Cys477

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

53.3 kDa

Observed Molecular Weight

50-65 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 0.05% Brij35, 10% Glycerol, pH 7.5.

Species

Human