Recombinant Human c-KIT/CD117 Protein (His Tag)

Specifications

Catalog number

PKSH033592-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor) . c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

Abbreviation

C-KIT; CD117

Synonyms

CD117; Mast/stem cell growth factor receptor Kit; PBT; Piebald trait protein; Proto-oncogene c-Kit; SCFR; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

UniProt

P10721

Accession Number

P10721

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln26-Thr520

Field of Research

Signal Transduction; Tags & Cell Markers; Neuroscience; Cancer; Developmental Biology; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

56.5 kDa

Observed Molecular Weight

150 kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S0141813020331901

Species

Human