Recombinant Human LFA-3/CD58 Protein (Fc Tag)

Specifications

Catalog number

PKSH033594-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lymphocyte function-associated antigen 3 (LFA-3/CD58) is a single-pass type I membrane protein. CD58 is widely expressed on hematopoietic and non-hematopoietic human tissue and has been found on leukocytes; erythrocytes; endothelial cells; epithelial cells and fibroblasts of human origin. It is a Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells; antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition; the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

Abbreviation

LFA-3; CD58

Synonyms

Ag3; CD58; CD58 antigen; LFA3; Lymphocyte Function-Associated Antigen 3; Surface Glycoprotein LFA-3

UniProt

P19256

Accession Number

AAH05930

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Phe29-Arg215

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.6 kDa

Observed Molecular Weight

60-90 kDa

Species

Human