Recombinant Human Interleukin-2/IL-2 Protein (Mutant)

Specifications

Catalog number

PKSH033625-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-2 (IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system; belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells.

Abbreviation

Interleukin-2; IL-2

Synonyms

IL2; IL-2; TCGF; lymphokine; IL3; IL4; IL5; IL6; Aldesleukin; IL-2lymphokine; interleukin-2; Proleukin; interleukin 2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; IL 2; IL2; Interleukin 2; interleukin2; Involved in regulation of T cell clonal expansion; Lymphokine; POIL2; T Cell Growth Factor; TCGF

UniProt

P60568

Accession Number

P60568

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala21-Thr153 (L100F, R101D, L105V, I106V, I112F)

Applications

Cell culture

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.5 kDa

Observed Molecular Weight

16&18 kDa

Species

Human