Recombinant Human Interleukin-18/IL-18 Protein

Specifications

Catalog number

PKSH033626-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production; and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine; and thus negatively regulate its biological activity. After stimulation with IL-18; natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

Abbreviation

Interleukin-18; IL-18

Synonyms

MGC; IL1F; IL-1F; IL18; IGIF; IL-18; IL-1g; IL1F4; GIF; Iboctadekin; IFN-gamma-inducing factor; IL-1 gamma; IL-1F4; Interferon gamma-inducing factor; Interferon-gamma-inducing factor; Interleukin 18; Interleukin-1 gamma; Interleukin-18; MGC12320; IFN gamma inducing factor; IL 1 gamma; IL 18; IL 1g; IL1 gamma; IL18 protein; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin 18 (interferon-gamma-inducing factor) ; Interleukin18

UniProt

Q14116

Accession Number

Q14116

Expression System

E.coli

Tag

None

Sequence

Tyr37-Asp193

Applications

Cell culture

Field of Research

Cancer; immunology; metabolism

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.2 kDa

Observed Molecular Weight

15 kDa

Species

Human