Recombinant Human Interleukin-17D/IL-17D Protein

Specifications

Catalog number

PKSH033627-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence homology. IL-17D is expressed preferentially in skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Like other IL-17 family members, IL-17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines including IL-6, IL-8, and GM-CSF. IL-17D has also been shown to suppress the proliferation of myeloid progenitors in colony formation assays.

Abbreviation

Interleukin-17D; IL-17D

Synonyms

UNQ; IL 27; IL-27; IL 17D; IL 22; IL-17D; IL27; Interleukin 17D; Interleukin 27; Interleukin-17D; Interleukin-27; IL17D; UNQ3096; PRO21175

UniProt

Q8TAD2

Accession Number

Q8TAD2

Expression System

E.coli

Tag

N-His

Sequence

Ala18-Pro202

Field of Research

Cancer; immunology

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

21.0 kDa

Observed Molecular Weight

17-34 kDa

Species

Human