Recombinant Human IFN-λ1/IL-29 Protein (His Tag)

Specifications

Catalog number

PKSH033639-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-29 (IL-29) is a secreted protein which belongs to the IL-28/IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10R beta) and an orphan class II receptor chain, designated IL-28R alpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Abbreviation

IFN-λ1; IL-29

Synonyms

IFN-lambda; Interleukin; ytokine Zcyto; Cytokine Zcyto; IFNL; ZCYTO; IFN-λ; lambda; Cytokine Zcyto21; IFN-lambda-1; IFN-λ1; IL-29; interferon; interferon lambda 1; Interferon lambda-1; Interleukin-29; lambda 1; ytokine Zcyto21; IL29; ZCYTO21; IFNL1

UniProt

Q8IU54

Accession Number

Q8IU54

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gly20-Thr200

Field of Research

Microbiology; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

21.4 kDa

Observed Molecular Weight

28-35 kDa

Species

Human