Recombinant Human ROR1 Protein (Fc Tag)

Specifications

Catalog number

PKSH033648-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ROR1, also known as Neurotrophic tyrosine kinase, receptor-related 1, belongs to the ROR subfamily of Tyr protein kinase family, a protein kinase superfamily. It has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. Human ROR1 shares 97% and 58% aa sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. Its Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Abbreviation

ROR1

Synonyms

Inactive tyrosine-protein kinase transmembrane receptor ROR1; NTRKR1; Neurotrophic tyrosine kinase; ROR1; receptor-related 1

UniProt

Q01973

Accession Number

Q01973

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln30-Glu403

Field of Research

Signal Transduction; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

68.9 kDa

Observed Molecular Weight

90-110 kDa

Species

Human