Recombinant Human PSMA Protein (His Tag)

Specifications

Catalog number

PKSH033667-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level) . PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.

Abbreviation

PSMA

Synonyms

Cell growth-inhibiting gene 27 protein; FGCP; FOLH; FOLH1; Folate hydrolase 1; GCP2; GCPII; Glutamate carboxypeptidase 2; Mgcp; NAALAD1; NAALADase I; NAALAdase; PSM; PSMA; mGCP

UniProt

Q04609

Accession Number

Q04609

Expression System

HEK293 Cells

Tag

N-His

Sequence

Lys44-Ala750

Field of Research

Signal Transduction; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

80.6 kDa

Observed Molecular Weight

90-120 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 5% Trehalose, pH 5.5.

Species

Human