Recombinant Human SerpinE2/SERPINE2 Protein (His Tag)

Specifications

Catalog number

PKSH033671-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown that Serpin E2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from the onset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.

Abbreviation

SerpinE2; SERPINE2

Synonyms

GDN; Glia-derived Nexin; PI-7; PI7; PN-1; PN1; Peptidase inhibitor 7; Protease nexin 1; Protease nexin I; SERPINE2; Serpin E2

UniProt

P07093

Accession Number

P07093-2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser20-Pro397

Field of Research

Neuroscience, Cardiovascular, Cell Biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

42.7 kDa

Observed Molecular Weight

50 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Species

Human