Recombinant Human Fibronectin/FN Protein (His & Avi Tag)

Specifications

Catalog number

PKSH033677-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins; fibronectin binds extracellular matrix components such as collagen; fibrin; and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion; growth; migration; and differentiation; and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression; degradation; and organization has been associated with a number of pathologies; including cancer and fibrosis. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer; named superfibronectin; exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth; angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Abbreviation

Fibronectin; FN

Synonyms

CIG; ED-B; FINC; FN; FN1; FNZ; Fibronectin; GFND; GFND2; LETS; MSF

UniProt

P02751

Accession Number

P02751-15

Expression System

E.coli

Conjugation

Biotinylated

Tag

N-His-Avi

Sequence

Glu1266-Thr1356

Field of Research

Signal Transduction; Cardiovascular; Cancer; Developmental Biology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.4 kDa

Observed Molecular Weight

15 kDa

Species

Human