Recombinant Human DPP4/DPPIV/CD26 Protein (His Tag)

Specifications

Catalog number

PKSH033695-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. CD26 is expressed specifically in lymphatic vessels but not in blood vessels in the skin; small intestine; esophagus; ovary; breast and prostate glands. It acts as a positive regulator of T-cell coactivation; by binding at least ADA; CAV1; IGF2R; and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM) ; the migration and invasion of endothelial cells into the ECM. It may be involved in the promotion of lymphatic endothelial cells adhesion; migration and tube formation. When overexpressed; it enhanced cell proliferation; a process inhibited by GPC3. It acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation; including many chemokines; mitogenic growth factors; neuropeptides and peptide hormones.

Abbreviation

DPP4; DPPIV; CD26

Synonyms

ADABP; ADCP-2; Adenosine deaminase complexing protein 2; DPP IV; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; T-cell activation antigen CD26

UniProt

P27487

Accession Number

P27487

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asn29-Pro766

Field of Research

Cell biology; Cancer; immunology; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

86.4 kDa

Observed Molecular Weight

90-130 kDa

Species

Human