Recombinant Human CHI3L2/YKL-39 Protein (His Tag)

Specifications

Catalog number

PKSH033718-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chitinase 3-Like Protein 2 (CHI3L2) is a 39 kDa secreted glycoprotein which belongs to the glycosyl hydrolase 18 family and the most closely related to human cartilage glycoprotein 39, which promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. Highest expression of CHI3L2 is in chondrocytes, followed by synoviocytes, lung and heart. It is not detected in spleen, pancreas, and liver. CHI3L2 may also be expressed in developing brain and placenta. Increased levels of CHI3L2 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis as well as in some other pathologies and in malignant tumors, particularly in glioblastomas. CHI3L2 may bind glycan structure with high affinity, but not heparin. It has has no chitotriosidase activity, but is likely to bind some type of glycan.

Abbreviation

CHI3L2; YKL-39

Synonyms

CHI3L2; CHIL2; Chitinase-3-Like Protein 2; Chondrocyte Protein 39; YKL-39; YKL39

UniProt

Q15782

Accession Number

AAH11460.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Tyr27-Leu390

Field of Research

Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

41.9 kDa

Observed Molecular Weight

40 kDa

Species

Human