Recombinant Human CDO/CDON Protein (His Tag)

Specifications

Catalog number

PKSH033720-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CDO (CAMrelated/down-regulatedby oncogenes) is a member of the Immunoglubulin (Ig) superfamily, Ig/Fibronectin (FN) type III repeat family of cell surface proteins. Human CDO is a type I transmembrane (TM) glycoprotein. It is synthesized as a 1287 amino acid (aa) precursorthat contains a 25 aa signal sequence, a 938 aa extracellular domain (ECD), a 21 aa TM segment and a 303 aa cytoplasmic region. The ECD contains five C2-typeIglikedomains, followed by three FN type III repeats. The ECD of human CDO is 85% aa identical to mouse CDO ECD.CDO is found on muscle precursor and neural progenitor cells of the embryo. It likely promotes muscle differentiation, and contributes to axon guidance andneuronal patterning.

Abbreviation

CDO; CDON

Synonyms

CDO; CDON; Cell adhesion molecule-related/down-regulated by oncogenes

UniProt

Q4KMG0

Accession Number

Q4KMG0

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp26-Pro943

Field of Research

Epigenetics and nuclear signal; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

100.4 kDa

Observed Molecular Weight

120-135 kDa

Species

Human