Recombinant Human CCL23 Protein

Specifications

Catalog number

PKSH033734-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Chemokine (C-C Motif) Ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1, CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 amino acid residue signal peptide that is cleaved to generate a 99 amino acid residue mature CCL23 (amino acids 22 -120) . Additional N-terminal Processing of the 99 amino acid residue variant can generate a 75 amino acid residue peptide (amino acid 46-120) that is significantly more active than the 99 amino acid residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes, dendritic cells, and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells, but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.

Abbreviation

CCL23

Synonyms

C-C Motif Chemokine 23; CCL23; CK-Beta-8; CKB-8; MIP-3; MIP3; MPIF-1; MPIF1; Macrophage Inflammatory Protein 3; Myeloid Progenitor Inhibitory Factor 1; SCYA23; Small-Inducible Cytokine A23

UniProt

P55773

Accession Number

P55773

Expression System

E.coli

Tag

None

Sequence

Arg46-Asn120

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

8.7 kDa

Observed Molecular Weight

11 kDa

Species

Human