Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag)

Specifications

Catalog number

PKSH033741-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. CAMK1 contains one protein kinase domain and widely expressed. CAMK1 is phosphorylated by CaMKK1 and CaMKK2 on Thr-177. CAMK1 regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, and neurite outgrowth. CAMK1 plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex.

Abbreviation

CAMK1; CaMKI-alpha

Synonyms

CAMK1; CaM Kinase I; CaM Kinase I Alpha; CaM-KI; CaMKI-Alpha; Calcium/Calmodulin-Dependent Protein Kinase Type 1

UniProt

Q14012

Accession Number

Q14012

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Leu370

Field of Research

Signal Transduction; Cardiovascular; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.3 kDa

Observed Molecular Weight

42 kDa

Species

Human