Recombinant Human Fibrillin-1/FBN1 Protein (His Tag)

Specifications

Catalog number

PKSH033759-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In the liver asprosin activates rapid glucose release by a cAMP-dependent pathway. The glucose release by the liver into the blood stream is vital for brain function and survival during fasting. People with neonatal progeroid syndrome lack asprosin, while people with insulin resistance have it in abundance. In animal tests asprosin showed potential for treating type 2 diabetes. When antibodies targeting asprosin were injected into diabetic mice, blood glucose and insulin levels improved.

Abbreviation

Fibrillin-1; FBN1

Synonyms

ECTOL; GPHYSD; MFS; FBN1; ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; WMS; WMS2;350 kDa glycoprotein component extracellular microfibril; Asprosin; FBN 1; Fibrillin 15; Fibrillin1; Fibrillin-1; Fibrillin15; Marfan syndrome; MFS 1; Weill Marchesani syndrome; THBD; THRM

UniProt

P35555

Accession Number

P35555

Expression System

HEK293 Cells

Tag

N-His

Sequence

Ser2732-His2871

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17 kDa

Observed Molecular Weight

25-35 kDa

Species

Human