Recombinant Human ANGPTL7 Protein (His Tag)

Specifications

Catalog number

PKSH033766-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Its production is up-regulated in trabecular meshwork cells by glucocorticoids and TGF-β and in cartilage by TNF-α. Overexpression of ANGPTL7 in trabecular meshwork cells inhibits the production of collagen and proteoglycans. When overexpressed in tumor cells it promotes collagen and proteoglycan deposition but inhibits tumor xenograft progression and tumor angiogenesis.

Abbreviation

ANGPTL7

Synonyms

ANGPTL7; Angiopoietin-like factor; Angiopoietin-like protein 7; Angiopoietin-related protein 7; CDT6; Cornea-derived transcript 6 protein

UniProt

O43827

Accession Number

O43827

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln27-Pro346

Field of Research

Neuroscience; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.4 kDa

Observed Molecular Weight

34、45-55 kDa

Species

Human