Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)

Specifications

Catalog number

PKSH033782-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-βsuperfamily of ligands. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. The mutations of ALK-1 are associated with Rendu-Osler-Weber syndrome 2, this suggests ACVRL1 is associated with blood vessel development and repair.

Abbreviation

ALK-1; ACVRL1

Synonyms

ACVRL1; ACVRLK1; ALK-1; ALK1; Activin Receptor-Like Kinase 1; HHT; HHT2; ORW2; SKR3; Serine/Threonine-Protein Kinase Receptor R3; TGF-B Superfamily Receptor Type I; TSR-I

UniProt

P37023

Accession Number

P37023

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Asp22-Gln118

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.6 kDa

Observed Molecular Weight

50-65 kDa

Species

Human