Recombinant Human CCL1/I-309 Protein

Specifications

Catalog number

PKSH033809-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chemokine (C-C Motif) Ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells, which play a central role during immunoregulatory and inflammaion processes. Human CCL1 has been assumed to be a homologue of the mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with cell surface chemokine receptor CCR8. CCL1 is identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection.

Abbreviation

CCL1; I-309

Synonyms

CCL1; C-C Motif Chemokine 1; SCYA1; Small-Inducible Cytokine A1; T Lymphocyte-Secreted Protein I-309

UniProt

P22362

Accession Number

P22362

Expression System

E.coli

Tag

None

Sequence

Lys24-Lys96

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

8.6 kDa

Observed Molecular Weight

10 kDa

Species

Human