Recombinant Human KIM-1 (C-6His)

Specifications

Catalog number

PKSH033813

Size / count

1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kidney injury molecule-1 (KIM-1) (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. Therefore, KIM-1 is a suitable renal biomarker capable of early detection and progressive monitoring of acute kidney injury beyond traditional injury markers such as serum creatinine (SCr) and blood urea nitrogen (BUN) which lack specificity and sensitivity. KIM-1 has also been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.

Abbreviation

KIM-1

Synonyms

HAVCR; HAVCR-1; HAVCR1; Hepatitis A virus cellular receptor 1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD-1; TIMD1

UniProt

F1CME6

Accession Number

F1CME6

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser21-Gly290

Endotoxin

Please contact us for more information.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

29.8 kDa

Observed Molecular Weight

80-120 kDa

Formulation

Supplied as a 0.2 μM filtered solution of PBS, pH7.4,5% Trehalose

Species

Human