Recombinant Human G-CSFR/CD114/CSF3R (C-Fc)

Specifications

Catalog number

PKSH033845-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, the protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML) . Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

Abbreviation

G-CSFR; CD114; CSF3R

Synonyms

CD114; CD114 antigen; CSF3R; Csfgr; G-CSF R; G-CSF receptor; G-CSFR; GCSFR; GCSFRG-CSF-R; colony stimulating factor 3 receptor (granulocyte)

UniProt

Q99062

Accession Number

Q99062

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Glu25-His627

Field of Research

Cancer; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

93.7 kDa

Observed Molecular Weight

110-130 kDa

Species

Human