Recombinant Human CA125/MUC16 (C-6His)

Specifications

Catalog number

PKSH033847-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.

Abbreviation

CA125; MUC16

Synonyms

CA-125; CA125; CA125 ovarian cancer antigen; CA125MUC-16; FLJ14303; MUC16; cell surface associated; mucin 16; mucin-16

UniProt

Q8WXI7

Accession Number

Q8WXI7

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gly12660-Met12923

Field of Research

Signal Transduction; Tags & Cell Markers; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

29.2 kDa

Observed Molecular Weight

40-70 kDa

Citation 01

https://link.springer.com/article/10.1007/s00604-020-04593-0

Species

Human