Recombinant Human FAM3B (C-Fc)

Specifications

Catalog number

PKSH033848-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.

Abbreviation

FAM3B

Synonyms

CDw329; Protein FOAP-9; SIGLEC9; Sialic acid-binding Ig-like lectin 9; Siglec-9

UniProt

P58499

Accession Number

P58499

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Glu30-Ser235

Field of Research

Immunology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

50.0 kDa

Observed Molecular Weight

50-65 kDa

Species

Human