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Product details

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)

Catalog number PKSH033851-01

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Price for PKSH033851-01

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Size / count 10 µg

Specifications

Catalog number
PKSH033851-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO--terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.
Abbreviation
Siglec-15; CD33L3
Synonyms
425O18-1; Angiopoietin-like protein 4; Angiopoietin-related protein 4; Angptl4; Farp; Fasting-induced adipose factor; Fiaf; HFARP; Hepatic fibrinogen/angiopoietin-related protein; Ng27; Secreted protein Bk89
UniProt
Q6ZMC9
Accession Number
Q6ZMC9
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Phe20-Thr263
Applications
BLI
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Loaded Human Siglec-15-Fc on AHC Biosensor, can bind Anti-Human Siglec15 mAb-mFc with an affinity constant of 0.13 nM as determined in BLI assay.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
53.5 kDa
Observed Molecular Weight
50-80 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)?

The catalog number for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is PKSH033851.

What sizes are available for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)?

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) come in?

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is available in 2 different pack sizes.

Is Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) in stock?

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)?

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)?

Estimated delivery time for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)?

The safety data sheet for Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc) is available here: https://789.bio/eb/f9a5m5.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

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