Recombinant Human CD27 Ligand/TNFSF7/CD70 (C-mFc)

Specifications

Catalog number

PKSH033858-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Abbreviation

TNFSF7; CD70

Synonyms

CD27 ligand; CD27L; CD27LG; CD70; CD70 antigen; TNFSF7; Tumor necrosis factor ligand superfamily member 7

UniProt

P32970

Accession Number

P32970

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Gln45-Pro193

Field of Research

Cancer; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

43.0 kDa

Observed Molecular Weight

50-60 kDa

Species

Human